IHEC Celebrates Major Coordinated Paper Release

Eurice supports global communication activities around the release

One of the great mysteries in biology is how the many different cell types that make up our bodies are derived from a single cell and from one DNA sequence, or genome. We have learned a lot from studying the human genome, but have only partially unveiled the processes underlying cell determination. The identity of each cell type is largely defined by an instructive layer of molecular annotations on top of the genome – the epigenome – which acts as a blueprint unique to each cell type and developmental stage. Unlike the genome the epigenome changes as cells develop and in response to changes in the environment. Defects in the factors that read, write and erase the epigenetic blueprint are involved in many diseases. The comprehensive analysis of the epigenomes of healthy and abnormal cells will facilitate new ways to diagnose and treat various diseases, and ultimately lead to improved health outcomes.

A collection of 41 coordinated papers now published by scientists from across the International Human Epigenome Consortium (IHEC) sheds light on these processes, taking global research in the field of epigenomics a major step forward. A set of 24 manuscripts has been released as a package in Cell and Cell Press-associated journals, and an additional 17 papers have been published in other high-impact journals.

These papers represent the most recent work of IHEC member projects from Canada, the European Union, Germany, Japan, Singapore, and the United States. The collection of publications showcases the achievements and scientific progress made by IHEC in core areas of current epigenetic investigations.

“This constitutes a major achievement for IHEC. The number of papers and variety of topics addressed by this creative team of scientists from around the globe not only reflects the dynamic nature of this consortium, but is also evidence of the great strength that comes from bringing together complementary expertise, with the potential for far greater impact than an equivalent number of individual projects”, said Dr. Eric Marcotte from the Canadian Institutes of Health Research (CIHR) and Chair of the IHEC Executive Committee.

Involved in the two IHEC-associated projects BLUEPRINT and DEEP – the German Epigenome Program, the communications team at Eurice runs the Communications Working Group within IHEC. As part of this engagement Eurice has been supporting the planning and coordination of global communication activities to accompany the release of this extensive set of papers.

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