Acronym
NOTOX

Full Title
Predicting long-term toxic effects using computer models based on systems characterization of organotypic cultures

Programme
FP7/Large-Scale Collaborative Project

Contract Number
267038

Abstract
The major aim of the NOTOX consortium is to develop and validate predictive mathematical and bioinformatic models characterizing long term toxicity responses. NOTOX will develop and establish a spectrum of systems biological tools including experimental and computational methods for organotypic human cell cultures suitable for long term toxicity testing and the identification and analysis of pathways of toxicological relevance. Data obtained in the course of the project will be organised in a toxicological database and/or incorporated into large-scale computer models that are based on material balancing and kinetics. Various “-omics” data and 3D structural information from organotypic cultures will be integrated using correlative bioinformatic tools. These data also serve as a basis for large scale mathematical models. The overall objective is to identify cellular and molecular signatures allowing prediction of long term toxicity, to design experimental systems for the identification of predictive endpoints and to integrate these into causal computer models.

Duration
60 months (01/01/2011 – 31/12/2015)

Project Funding
9,699,962.00  €

Coordinator
Saarland University
Biochemical Engineering
Prof. Elmar Heinzle
Phone: +49 681 302 2905
Email

Partners
Saarland University, Germany
Biochemical Engineering (Prof. Elmar Heinzle)
Genetics Institute (Prof. Jörn Walter)

National Centre of Scientific Research, France
Department of Analytical Sciences (Prof. Alain van Dorsselaer)

Netherlands Cancer Institute, The Netherlands
Division of Cell Biology (Prof. Peter Peters)

Karolinska Institute, Sweden
Department of Physiology and Pharmacology (Prof. Ingelman-Sundberg)

Insilico Biotechnology AG, Germany (Klaus Mauch)

National Institute for Research in Computer and Control Science, France (Prof. Dirk Drasdo)

German Research Centre for Artificial Intelligence GmbH, Germany
Agents and Simulated Reality (Prof. Phillip Slusallek)

Leibniz Research Centre for Working Environment and Human Factors, Germany
Toxicology (Prof. Jan Georg Hengstler)

Biopredic International, France (Dr. Christophe Chesné)

Weizman Institute of Science, Israel
Computer Science and Applied Mathematics (Dr. Amos Tanay)

Cambridge Cell Networks Ltd., United Kingdom (Dr. Gordana Apic)

European Research and Project Office GmbH, Germany (Claudia Giehl)

Contact at Eurice
Claudia Giehl
Senior Programme Manager
Phone: +49 681 9592 3378
Email

Project Website
www.notox-sb.eu